IN VITRO ACTIVITY OF CEFTAZIDIME/SULBACTAM AND CEFEPIME/ SULBACTAM IN COMBINATION AGAINST ESBL PRODUCING ISOLATES

The use of the ?-lactamase inhibitors in combination with the ?-lactam antibiotics is currently the most successful strategy used for
circumventing the resistance mechanisms. The aim of the study was to compare the in–vitro activity of ceftazidime/sulbactam and
cefepime/sulbactam in combination against ESBL producing gram negative isolates. In the present study all specimens were cultured
and isolates were identified by standard methods. The antimicrobial sensitivity testing was done according to CLSI guidelines by
Kirby Bauer’s disc diffusion method. The breaking point for antimicrobial sensitivity testing interpretation of these combinations was
provided by Venus Research Center. All readings were noted according to reference ranges provided by manufacturer for both the
antibiotic combinations.