DEVELOPMENT AND VALIDATION OF SIMULTANEOUS EQUATION METHOD FOR ESTIMATION OF MONTELUKAST SODIUM AND LEVOCETIRIZINE DIHYDROCHLORIDE BY UV SPECTROPHOTOMETRIC METHOD

A Simple, accurate, precise and rapid UV spectrophotometric method has been developed for the simultaneous estimation of Montelukast sodium and Levocetirizine dihydrochloride, in pure form. The stock solution was prepared in phosphate buffer (pH 6.8) followed by the further required dilutions with pH 6.8. This method involves the formation and solving of simultaneous equation at 245 and 231nm, as absorbance maxima of Montelukast sodium and Levocetirizine dihydrochloride, respectively. Beer’s law obeyed the concentration range of 5-30 mcg/ml and 4-24 mcg/ml, for Montelukast sodium and Levocetirizine dihydrochloride, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than two. Theproposed method can be effectively applied for the simultaneous estimation of two drugs in bulk and in combined dosage form


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