Fast dissolving drug delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the fastest, safest,
convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets.
The goal of this study was to formulate and evaluate fast dissolving tablets (FDTs) of Metoclopramide hydrochloride so as to
overcome swallowing difficulties. The key to develop successful FDT formulations by the direct compression method is to select the
right superdisintegrant and compatible excipients depending on FTIR and DSC studies. Various formulations were prepared by direct
compression method using different concentrations of cross povidone (1.5% – 7.5%) as synthetic superdisintegrant and isolated
mucilage of Hibiscus rosasinensis (1.5% – 7.5%) as natural superdisintegrant. Formulations were evaluated for precompressional and
postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption
ratio, in vitro dispersion time, in vitro disintegration time and in vitro dissolution study.
Results revealed that among the 10 formulations, the formulation FCP5 containing 7.5% of crospovidone and formulation FHR5
containing 7.5% of Hibiscus rosasinensis was found to be promising formulation. FCP5 shown disintegration time of 9.33 seconds and
the drug release was up to 98.79% in 30 minutes and FHR5 shown disintegration time of 17.33 seconds and the drug release was up to
77.50% in 30 minutes.