With the advent of digital imaging technologies in medical field, there is a great demand for the quality of medical images or video sequences for the
accurate diagnosis of diseases. Magnetic Resonance Imaging (MRI) can only acquire images and video sequence with low resolution. High
resolution is of great importance for the better classification of regions, zooming of a specific area of interest or helping the visual analysis. A number
of interpolation techniques have been applied to enhance the resolution of images, but these classical approaches results in noise such as jagged edge
distortion and blurring of images. In this paper a modified cubic spline interpolation technique for the resolution enhancement of MRI frames is
proposed. The performance of proposed technique is evaluated using Peak Signal to Noise Ratio (PSNR).