Two analogs of Amidomycin, was synthesized by solution phase peptide synthesis using dicyclohexylcarbodiimide (DCC) as the
coupling agent and triethylamine (TEA) as the base. Configurational change of D- to L- on Valine was made on Amidomycin to
derive the compounds 1) Cyclo-L-[Val-Val-Val-Val-Val-Val-Val-Val] and 2) Cyclo-D-Val-L-[Val- Val-Val-Val-Val-Val-Val]. The
structure of these compounds was confirmed by IR, 1H NMR, 13C NMR, FABMASS and elemental analysis. The synthesized cyclic
peptides were evaluated for Minimum Inhibitory Concentration (MIC) against four strains of bacteria and three strains of fungi. All
compounds were found to be active against bacteria from 25-200µg and against fungi from 50-200µg.