CHEMICAL SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF P-HYDROXY ACETOPHENONE PRAMIPEXOLE AND ITS Cu(II), Ru(III) COMPLEXES

The present paper deals with the synthesis, characterization and DNA binding studies of metal complexes of newSchiffbase derived
from Pramipexole (N6-propyl-4,5,6,7-Tetrahydro-,1,3-benzothiazole-2,6-diamine). The bidentate ligand is derived from the inserted
condensation of pramipexole with P-hydroxy acetophenone (PHAPP) in a 1:1 molar ratio.Using this bidentate ligand, complexes of
Cu(II), Ru(II) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques
using Elementalanalysis, IR, NMR, UV-VisSpectrometry, ESR, TG-DTA and Conductometric measurements. The elemental analysis
data suggest that stoichiometry to be 1:2 [M:L]. All the complexes are non electrolytic in nature as suggested by molar conductance
measurements. Infrared spectral data indicate the co-ordination between ligand and central metal ion through deprotanated phenolic
oxygen and azomethine nitogen. In addition the authors have been screened the compounds for biological activity. It was found that
the compounds have shown activity against the organisms like Escherichia coli, Klebsiella and Bacillus subtilis.