SOLUTION PHASE SYNTHESIS AND ANTIMICROBIAL EVALUATION OF N-METHYLATED D-ANALOG OF AMIDOMYCIN

N-methylated D-analog of Amidomycin, was synthesized by solution phase peptide synthesis using ethyl-3-
dimethylaminopropylcarbodiimide (EDC) as the coupling agent and triethylamine (TEA) as the base. The structure of the
compound was confirmed by IR, 1H NMR, 13C NMR, FABMASS and elemental analysis. The synthesized cyclic peptide was
evaluated for Minimum Inhibitory Concentration (MIC) against four strains of bacteria and three strains of fungi. All compounds were
found to be active against both bacteria and fungi from 25-100µg.