HEPATOPROTECTIVE & ANTIOXIDANT EFFECT OF WHOLE PLANT EXTRACT OF POLYGONUMGLABRUM WILLD. ON CCL4 INDUCED HEPATIC DAMAGE IN RATS

The present work has been designed to evaluate hepatoprotective&in vivo antioxidant effect of Methanol-Aqueous Extract of whole
plant Polygonumglabrumwilld. (MAEP) against carbon tetrachloride(CCl4)- induced hepatotoxicity in experimental rats. The levels
of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase
(SALP), uric acid, total protein and total bilirubin were determined. Antioxidant status in liver was determined by measuring the
activity of malonaldehyde (MDA), glutathione (GSH), total thiol and catalase (CAT). Total wet weight and histopathological study of
isolated liver specimen was also carried out. . The oral pre-treatment with MAEP (200 and 400 mg/kg) showed significant
hepatoprotective activity against CCl4 induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and
lipid peroxidation, and significant increase in the levels of uric acid, GSH, Total thiol, Catalase and protein in a dose dependent
manner, which was confirmed by the decrease in the total weight of the liver and histopathological examinations. Data also showed
that MAEP possessed strong antioxidant activity, which may probably leads to the promising hepatoprotective activities of MethanolAqueous
Extract of whole plant Polygonum glabrum willd. (MAEP). These findings, therefore supported the traditional believes on
hepatoprotective effect of the whole plant Polygonum glabrumwilld.(MAEP).