DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF LINEAR TETRAPEPTIDE D-Ala-L-(Gly-Val-Val) (AGVV)

A rational designing of the linear tetrapeptide D-Ala-L-(Gly-Val-Val) (AGVV) was done and was synthesized by solution phase
peptide synthesis. The method includes synthesis of the tetrapeptide AGVV by using ethyl-3-dimethylaminopropylcarbodiimide
(EDC) as a coupling reagent and triethylamine (TEA) as the base. The molecular docking studies of the designed tetrapeptide AGVV
was carried out by using Molegro Virtual Docker software for anticancer properties. The synthesized compound was characterized by
FT-IR, 1H-NMR and Mass spectral data and was evaluated for antioxidant and anthelmintic activities. The linear tetrapeptide
exhibited moderate antioxidant activity and good anthelmintic activity.