Scabies is an acute communicable disease known as Pama in Ayurveda. Gandhaka Taila and Gandhaka Druti are well known drugs of
Ayurveda used in various skin disorders and Kshudra Kushtha. The present study is aimed to evaluate the clinical efficacy of
Gandhaka Taila and Gandhaka Druti on scabies. For this single blind clinical trial with two groups ‘A’ and ‘B’ of d diagnosed patients
of scabies was done. Group A received Gandhaka Druti for local application and 500mg Gandhaka Rasayana in two divided doses per
day internally; while group B received Gandhaka Taila for local application and Gandhaka Rasayana 500 mg in two divided doses per
day internally. The duration of study was twenty one days. The subjective and objective observations were evaluated statistically using
t-test. The results suggested that both the drugs are effective in scabies, but Gandhaka Taila was a little more effective statistically.